چکیده

The role of guarana plant extract in cancer treatment Agrin mansouri1* seyed morteza Javadirad 2 1 BS student of cell biology Department of Cell and Molecular Biology and Microbiology Faculty of Biological Science and technology University of Isfahan Isfahan Iran 2 Assistant professor of molecular genetics Department of Cell and Molecular Biology and Microbiology Faculty of Biological Science and technology University of Isfahan Isfahan Iran corresponding author Email agrin.msor@gmail.com Statement of Problem Patients with breast cancer (BC) frequently undergo systemic chemotherapy which can cause cancer-related fatigue and have a negative impact on the patients quality of life. Research Purpose To treat fatigue in BC patients after chemotherapy was tested using guarana (Paullinia cupana) extract as a stimulant. Description of the problem It is unclear whether guarana extract could help BC patients feel less tired and it would be interesting to learn more about how it works. Results and Conclusion When guarana dry extract was administered orally in doses of 30 100 and 300 mg kg the serum level of Interleukin 1 (IL-1) was found to have significantly decreased. The level of Interleukin 6 (IL-6) did not change significantly at the same time. It s interesting to note that guarana extract treatment significantly reduced the brain levels of IL-6 and tumour necrosis factor (TNF) mRNA that were elevated in stimulated animals. The expression of cyclooxygenase 2 (COX2) and nuclear factor kappa-light chain-enhancer of activated B cells (NF-kB) in brain tissue was later found to be significantly reduced by guarana extract according to data. Guarana therefore has anti-inflammatory properties which may account for its anti-fatigue effects. Guarana may also help with additional cancer-related symptoms that are brought on by an imbalance in the expression of anti-inflammatory cytokines. In conclusion after using the guarana plant to treat their cancer-related fatigue breast cancer survivors have reported a noticeable reduction in the frequency and intensity of hot flashes. For BC patients receiving temporary chemotherapy guarana is an alternative cost-effective and secure treatment option. Keywords breast cancer guarana fatigue

کليدواژه ها

breast cancer guarana fatigue

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