چکیده

An introduction to the effect of ginger derivatives on COVID-19 Statement of Problem Throughout human history pandemics has always been considered as a leading cause of death. In 2019 with the emergence of COVID-19 many researchers attention was directed toward using natural products as a treasure trove of bioactive compounds for drug development and disease treatment. Ginger Zingiber officinale is one of those plants which has a prominent place in traditional and modern medicine. Research Purpose Considering the favorable effects of ginger extracts in various inflammatory and viral diseases the aim of this study was to examine the performance of the constituents of this remedial plant in the face of the COVID-19 pandemic. Research Method All the scientific reports and academic manuscripts regarding ginger derivatives and their role in COVID-19 published from 2018-2023 were collected from PubMed and diligently classified. Results and Conclusion Studies indicate that ginger has more than 400 chemical structures such as phenolic compounds and terpenes with a wide range of activities. Considering the critical role of oxidative stress and inflammation in the progression of COVID-19 ginger derivatives can indirectly affect the reduction and treatment of the disease. Among them 6-shogaol is of great importance according to its antioxidant and anti-inflammatory properties. On the other hand In silico studies have shown direct interactions between some ginger constituents and different components of COVID-19. Gingerenone A with its high affinity binding to the D614G SARS-CoV-2 spike protein and 8 or 10-gingerol showing substantial arrangements at the dynamic site of the SARS‑CoV‑2 main protease receptor are derivatives which may directly intercept the virus by its neutralization. In conclusion ginger constituents may both directly and indirectly block the pathologic activities of the coronavirus. These data may help developing new anti-viral therapeutic strategies against COVID-19.

کليدواژه ها

COVID-19 Ginger Anti-inflammatory Antioxidant

کد مقاله / لینک ثابت به این مقاله

برای لینک دهی به این مقاله، می توانید از لینک زیر استفاده نمایید. این لینک همیشه ثابت است :

نحوه استناد به مقاله

در صورتی که می خواهید در اثر پژوهشی خود به این مقاله ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
سهیلا رهگذر , 1402 , مقدمه ای بر تاثیر مشتقات زنجبیل بر روی COVID-19 , كنگره بين المللي فرآورده‌هاي طبيعي شفابخش