چکیده

Introduction With the emergence of multidrug resistance (MDR) bacteria it is necessary to find novel antimicrobial agents for treating such bacteria. Natural products are a rich source of bioactive compounds and are used for the treatment of a wide range of human infections. Recent studies primarily focus on herbal products due to their effectiveness as sources of antimicrobial compounds. For example flavonoids have been recognized as having a protective effect in plants against phytopathogens.. Tribulus terrestris L. (Zygophyllaceae) is a popular plant in traditional European and Chinese folk medicine .. Considering the importance of herbal products as treatments for infectious diseases the antimicrobial activity of aqueous and ethanolic extracts of the. Tribulus terrestris L. (Zygophyllaceae) from Guilan province Iran on MDR Enterobacter isolates from patients suffering from UTI were examined in the current. Material and methods Aqueous and alcoholic extracts of Tribulus terrestris were prepared using conventional methods. Bacteria were isolated from urine samples of patients with urinary tract infections (UTIs). Antimicrobial activity was evaluated by well diffusion method MIC determination antibiofilm assay. After observing the antimicrobial effect of the extracts the effect of the extracts was analyzed on pathogenesis genes expression of Enterobacter using Real Time PCR.. All the tests were repeated three times and the data were reported as mean ± SD. The data were statistically analyzed using One-way analysis of variance (ANOVA) and differences among the means were determined at P ≤ 0.01. Results . The antimicrobial tests showed that the extracts have significant antimicrobial effects. Also molecular analysis was confirmed that medium to high concentrations of extracts significantly reduce the expression of pathogenic genes. Conclusion The extracts of T. terrestris (TT) are good candidates to use in the treatment of UTI due to MDR Enterobacter although they need more investigation.

کليدواژه ها

Key word Tribulus terrestris antimicrobial Enterobacter

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اکبر نورسته نیا , 1402 , تاثیر عصاره گیاه خارخاسک(Tribulus terrestris )روی بیان ژن های دخیل در بیماری زایی انتروباکتر , كنگره بين المللي فرآورده‌هاي طبيعي شفابخش